Fun Friday: Funding in Transition and Mammalian Distributed Memory Storage

As inflation continues to take its toll on everyone’s investments as well as steak dinner (psst – get the rotisserie chicken at Costco instead), Silicon Valley is clearly in a state of transition. Startups have been told to tighten their belts financially. Layoffs in big tech companies have begun. “Growth” ventures are failing to get follow-on funding, primarily in the consumer space and media (in Substack’s case, they’re also proving the old adage that no one pays attention to writers).

But for every easy money gambit that’s falling out of the sky, there is hope for the dreamer and rogue. Venture firms are still collecting money hand-over-fist from desperate Limiteds eager to get some return with the stock market slowing. Folks with money want to make more money. There are lots of them.

Of course, this doesn’t directly help the small entrepreneur. Big Venture (TM) doesn’t fund the small fry inventing neat technologies anymore — they have too many Series D unicorn mouths to feed. Big tech companies are no longer a safe bet — they may fire you and escort you unceremoniously out the door without any warning. In hard times, loyalty is not its own reward.

But there are a lot of individual investors out there who can drop $1M on a neat tech idea. All the startups William and I founded started with a dream, some code, and a handshake during lousy economic times. They were funded precisely because making easy money on scams and gambits have evaporated.

So if you’ve got a good hard tech project, now may be the best time to go for it. The cash is still plentiful. Just play it cool. It worked for us. It can work for you.

Researchers tracked neural activity across a whole mouse brain to determine what areas were involved in storing a specific memory. Many brain regions found likely to be involved in encoding a memory (top) were also found to be involved in recall upon reactivation (bottom).
Credits: Image courtesy of the Tonegawa Lab/Picower Institute.
Neural activity across a whole mouse brain to determine what areas were involved in storing a specific memory. Many brain regions found likely to be involved in encoding a memory (top) were also found to be involved in recall upon reactivation (bottom). 
Credits:Image courtesy of the Tonegawa Lab/Picower Institute. Read the article!

And speaking of distributed memory, a new study from MIT describes the mammalian brain as storing memory, not densely in a few regions, but instead loosely across many regions of the brain. This makes sense in a way. It’s a lot easier to completely lose a memory if it’s in one or a few locations than spread throughout the brain. Also, storing memories in larger “chunks” would result in a lot of wasted storage space since a memory is of varying size. Indirect references to each memory element, even if a few are lost, are more efficient than directly physically mapping a memory.

It does explain the dreamlike aspect of memories, doesn’t it? And also perhaps memories which are completely wrong but feel entirely real and true. Likely we lose a lot of these references that fill in some of the blanks over time. Associated elements, like smell, can track back along a pathway to a memory to give the gist of it, but it may be only a shadow of what was actually recorded.

But is the brain’s memory sparsely allocated as well? It may well be given this highly distributed storage across many parts of the brain. Sparse allocation is common in operating systems because it is usually faster and overall more efficient. But it can use more total memory than that of a densely allocated memory mechanism if most of the elements contain non-repeatable data. Are most of our memories just collages of a few meaningful pieces and a lot of filler? Perhaps dreams look odd precisely because they are just stray strands of sparse referents to redundant memories garbage collected by the brain and reallocated for use.

To dream. Perchance to sleep. Now that is the question.

Not-So-Fun Friday: William Jolitz in Memoriam

I’ve avoided writing about many things over the last few years of William’s long illness. Writing his obituary was one of the most difficult things I’ve ever done. He lived an amazing life full of discovery, wonder and terror. Selecting just a few vignettes to illustrate his character and strength of will was difficult. I miss him terribly.

For the last six months of his life and the first three months of his death, I avoided the Los Gatos office we shared over the years. There are so many projects we planned that are now left undone. Some I can finish. Others I must deconstruct. Some are lost forever, except in my memory.

But now here I am in the little office I shared with William, surrounded by the relics of technologies and products and startups past. The passion is never extinguished, but only delayed a little.

Much in the world has changed but still stays exactly the same. Things William and I and others no one else remembers get rediscovered again and again. Things that shouldn’t be get dug up and instantiated with a “This time for sure” enthusiasm that belies sense. All for fame, or fortune, or just because it’s fun. It’s the Silicon Valley way.

And because memory is in the end all we have.